基因与足球运动员状态、身体表现和受伤风险的关联
International Journal of Sports Medicine
(
IF
2.2
)
Pub Date : 2023-08-09
, DOI:
10.1055/a-2103-0165
Conall F. Murtagh
1,
2
,
Elliott C. R. Hall
1,
3
,
Thomas E. Brownlee
4
,
Barry Drust
4
,
Alun G. Williams
5,
6
,
Robert M. Erskine
1,
6
Affiliation
School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Sports Science Department, Liverpool Football Club and Athletic Grounds Ltd, Liverpool, United Kingdom.
Faculty of Health Sciences and Sport, University of Stirling, Stirling, United Kingdom.
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Manchester Metropolitan Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom.
Institute of Sport, Exercise and Health, University College London, London, United Kingdom.
本综述的目的是批判性地评价有关遗传与运动员状态、身体表现和足球受伤风险之间关系的文献。目的是就哪些遗传标记可能被用作未来足球实践的一部分提供指导，并为该领域的未来研究提供方向。最令人信服的证据表明，六种基因多态性与足球运动员状态相关（ ACE I/D； ACTN3 rs1815739； AGT rs699； MCT1 rs1049434； NOS3 rs2070744； PPARA rs4253778），其中六种与身体表现相关（ ACTN3 rs1815739； AMPD1 rs17602729； BDNF rs ） 6265 ； COL2A1 rs2070739； COL5A1 rs12722； NOS3 rs2070744），以及七个有受伤风险的基因（ ACTN3 rs1815739； CCL2 rs2857656； COL1A1 rs1800012； COL5A1 rs12722； EMILIN1 rs2289360； IL6 rs1800795； MMP3 rs679620)。除了独立群体的复制之外，还需要进行大规模全基因组关联研究来识别新的遗传标记。未来的研究还应该研究这些多态性与特定表型相关的生理机制。此外，研究人员应该调查女性和非白人足球运动员的上述关联，因为几乎所有已发表的研究都招募了欧洲血统的男性参与者。只有在生成可靠的、独立复制的基因数据后，基因测试才能被视为可能为未来足球实践提供信息的额外工具。
"点击查看英文标题和摘要"
The Genetic Association with Athlete Status, Physical Performance, and Injury Risk in Soccer
The aim of this review was to critically appraise the literature concerning the genetic association with athlete status, physical performance, and injury risk in soccer. The objectives were to provide guidance on which genetic markers could potentially be used as part of future practice in soccer and to provide direction for future research in this area. The most compelling evidence identified six genetic polymorphisms to be associated with soccer athlete status (ACE I/D; ACTN3 rs1815739; AGT rs699; MCT1 rs1049434; NOS3 rs2070744; PPARA rs4253778), six with physical performance (ACTN3 rs1815739; AMPD1 rs17602729; BDNF rs6265; COL2A1 rs2070739; COL5A1 rs12722; NOS3 rs2070744), and seven with injury risk (ACTN3 rs1815739; CCL2 rs2857656; COL1A1 rs1800012; COL5A1 rs12722; EMILIN1 rs2289360; IL6 rs1800795; MMP3 rs679620). As well as replication by independent groups, large-scale genome-wide association studies are required to identify new genetic markers. Future research should also investigate the physiological mechanisms associating these polymorphisms with specific phenotypes. Further, researchers should investigate the above associations in female and non-Caucasian soccer players, as almost all published studies have recruited male participants of European ancestry. Only after robust, independently replicated genetic data have been generated, can genetic testing be considered an additional tool to potentially inform future practice in soccer.
更新日期：2023-08-10